Nanopore sequencing is a third generation approach used in the sequencing of biopolymers- specifically, polynucleotides in the form of DNA or RNA. Using nanopore sequencing, a single molecule of DNA or RNA can be sequenced without the need for PCR amplification or chemical labeling of the sample.
Type
By Technology
Direct Current Sequencing
Exonuclease Sequencing
Synthetic DNA and Optical Reading Techniques Sequencing
Horizontal Tunneling Current Sequencing
Table1. Type by Technology
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Content
Direct Current Sequencing (a)
There is a difference between the strength of the current when the nanotube channel is open and when it is blocked by a strand of DNA.
( |# H" D( }$ Q. i% h, b8 dExonuclease Sequencing (b)
The exonuclease is connected to the top of the a hemolysin nanopore, and it cuts off dNMP (gold) at the end of the DNA strand one by one, and then dNMP enters the nanopore and passes through the cyclodextrin ligand, causing corresponding current changes.
Synthetic DNA and Optical Reading Techniques Sequencing (c)
The nucleotides in the DNA strand under test were replaced with 12bp oligomers.The converted DNA strand is hybridized with a molecular beacon, which falls off as it passes through the nanopore, releasing fluorescence that is read.
Horizontal Tunneling Current Sequencing (d)
When the DNA strand passes through the nanopore electrode, the transverse perforation electrode will undergo specific changes and then be sequenced.
Source: Secondary Sources, Expert Interviews and QYResearch, 2020
Table2. The Major Nanopore Sequencing Platform/Service Player in the Market
Source: Secondary Sources, Expert Interviews and QYResearch, 2020
Table 2. History of Gene Sequencing Technology
Source: Secondary Sources, Expert Interviews and QYResearch, 2020
From 2007 to 2013, the global gene sequencing market grew from $794 million to $4.5 billion, with a compound growth rate of 33%.The compound growth rate from 2013 to 2018 was 21%, and the global gene sequencing market reached 11.7 billion us dollars in 2018. From the regional distribution point of view, China and other southeast Asian markets grow the fastest, up to 20-25%.
Figure 1. Global Gene Sequencing Market Size (Value), (US$ Million), 2007- 2018
Source: Secondary Sources, Expert Interviews and QYResearch, 2020
The most notable application of nanotechnology in biomedicine is a technique called nanopore gene sequencing. It works by using an electric field to drive each single strand of DNA through nanoscale holes, or nanopores, in the film. When a single strand of DNA passes through the nanopore, the electrical current generated in the pore is recorded to identify the sequence of the gene coding on the single strand. The technology promises to significantly reduce the cost and speed of gene sequencing.
The third generation sequencing technology and single-cell genome sequencing occupy the technological commanding heights. Compared with the second generation sequencing, the third generation sequencing has a fast speed, Read long, can directly measure methylated DNA sequence, no need for PCR amplification, no base preference, and other advantages, but also has low accuracy and dependence defects such as dependent enzyme activity. We think it will be a long time before the 3rd generation sequencing technology can be commercialized, but the technology is constantly improving, with the accuracy The third generation sequencing technology is a long-term development trend for the improvement of accuracy, parallel sequencing ability and enzyme activity.
Figure 1. Global Single-Molecule Sequencing Market Size (Value), (US$ Million), 2015 VS 2020 VS 2026
Source: Secondary Sources, Expert Interviews and QYResearch, 2020
According to the patent output, the number of patent applications of the United States, Japan, the European Patent Office, the United Kingdom and South Korea ranks the top5 in the world, among which the number of patent applications of the United States far exceeds that of other countries, and the number of patent applications of China ranks the sixth in the world.
Figure 2. Global Gene Sequencing Market Share by Type in 2019
Source: Secondary Sources, Expert Interviews and QYResearch, 2020
Gene sequencing is clinically applied in reproductive health, individualized diagnosis and treatment, prevention and inheritance of tumors Diseases, infectious disease diagnosis and treatment, etc., will be extended to medical research (drug development, etc.) and non-medical industry (scientific research, food, agriculture, aquaculture, etc.).
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With industry-standard accuracy in analysis and high data integrity, the report makes a brilliant attempt to unveil key opportunities available in the global Nanopore Sequencing market to help players in achieving a strong market position. Buyers of the report can access verified and reliable market forecasts, including those for the overall size of the global Nanopore Sequencing market in terms of revenue.
Players, stakeholders, and other participants in the global Nanopore Sequencing market will be able to gain the upper hand as they use the report as a powerful resource. For this version of the report, the segmental analysis focuses on revenue and forecast by each application segment in terms of revenue and forecast by each type segment in terms of revenue for the period 2015-2026.
Regional and Country-level Analysis
The report offers an exhaustive geographical analysis of the global Nanopore Sequencing market, covering important regions, viz, North America, Europe, China, Japan, Southeast Asia, India and Central & South America. It also covers key countries (regions), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, UAE, etc.
The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by each application segment in terms of revenue for the period 2015-2026.
Competition Analysis
In the competitive analysis section of the report, leading as well as prominent players of the global Nanopore Sequencing market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.
On the whole, the report proves to be an effective tool that players can use to gain a competitive edge over their competitors and ensure lasting success in the global Nanopore Sequencing market. All of the findings, data, and information provided in the report are validated and revalidated with the help of trustworthy sources. The analysts who have authored the report took a unique and industry-best research and analysis approach for an in-depth study of the global Nanopore Sequencing market.
The following players are covered in this report:
Oxford Nanopore Technologies
Roche
Stratos Genomics
10X Genomics
Pacbio
Illumina
Thermo Fisher
...
Nanopore Sequencing Breakdown Data by Type
Direct Current Sequencing
Exonuclease Sequencing
Synthetic DNA and Optical Reading Techniques Sequencing
Horizontal Tunneling Current Sequencing
Nanopore Sequencing Breakdown Data by Application
Medical
Non-medical
Gene sequencing is clinically applied in reproductive health, individualized diagnosis and treatment, prevention and inheritance of tumors Diseases, infectious disease diagnosis and treatment, etc, will be extended to medical research (drug development, etc.) and non-medical industry (scientific research, food, agriculture, aquaculture, etc.).
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