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Intravesical nadofaragene firadenovec sustains a therapeutic response over 24 months in patients with nonmuscle-invasive bladder cancer  NMIBC  unresponsive to bacillus Calmette-Gueacute;rin  BCG , including in those with carcinoma in situ  CIS  or high-grade Ta/T1 alone. Investigators presented follow-up data from their original phase 3 trial at the AUA2021 Virtual Experience.Nadofaragene firadenovec represents a potential novel treatment option for patients with high-grade BCG-unresponsive NMIBC that advances the current treatment and demonstrates sustained durability of response, investigators concluded in 2 poster presentations.The nov stanley becher el gene therapy greatly increases expression of interferon alfa in bladder epithelial cells and has proven more eff stanley becher ectiv stanley deutschland e than instilling the cytokine itself, the University of Texas team explained.In the original phase 3 trial published in The Lancet Oncology  NCT02773849 , 103 patients had CIS  with or without Ta/T1  and 48 patients had high-grade Ta/T1 alone  without CIS . Within the CIS cohort, 55 patients  53.4%  had a complete response within 3 months of the first dose, and this response was maintained in 20 patients  36.4%  at 12 months. Within the non-CIS high-grade Ta/T1 cohort, 35 patients  72.9%  had a complete response within 3 months of the first dose and this response was maintained in 21 patients  43.8%  at 12 months. All patients without high-grade recurrence at 12 months continued to receive nadofaragene firad Xpic Business Briefs: Feb. 6, 2026
Ah, the All-Star Game, such a source of baseball celebration, of performance that has inspired and impressed.Enough of that, for a minute. We so often hear that baseball is a game built on failure. We also hear, frequently from players, that baseball is a business. Well, then, lets spend a little time on the combination of those two as we  stanley deutschland head into Tuesday nights mid-summer classic in San Diego.Here are the least valuable players at each position, with a little contract situation factored in, through the first half of the season.  All stats through Th stanley canada ursday. Catcher: Derek Norris, Padres.214, 11 home runs, 32 RBIsThe former Nationals farmhand, traded to Oakland in the deal that landed Gio Gonzalez, was an all-star for the Athletics in 2014. But he has struggled in his year-and-a-half with the Padres. His average is last in the National League. His on-base per stanley mug centage  .275  is the fifth-worst in baseball. Though he has thrown out would-be base stealers at precisely the league average  15 of 50, for 30 percent , the advanced metric of runs saved-stolen bases  a measure of how catchers not only throw out runners, but prevent them from even attempting a steal 鈥?is a middling 1.  Kansas Citys Salvador Perez is at 5.  Join your neighbors and subscribe!Award-winning coverage on breaking news and todays top stories in and around the Upper Valley. Whether it s arts, sports, opinion, world news,  or our archives and e-editions, youll have unlimited access to the Valley News  con
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